The Genomes of SARS-CoV-2 and Related Coronaviruses: Are Accessory Proteins Key for Pathogenesis?

Author(s): Saikat Samanta, Rudra Prasad Saha*

Journal Name: Coronaviruses
The World's First International Journal Dedicated to Coronaviruses

Volume 2 , Issue 7 , 2021


Article ID: e250621188925
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Abstract:

Objective: In January 2020, scientists deciphered the first genome of SARS-CoV-2 that has created a ravage in the world by infecting over 30 million people worldwide with above 0.95 million deaths as of mid-September 2020. With no potent therapeutics against COVID-19, researchers around the world are relentlessly working for the development of a vaccine that can ease the pain the world is suffering today, both in terms of economic and psychological instability. Understanding the genome of SARS-CoV-2 is essential to decipher the keys that would help scientists to develop drugs or vaccines to prevent the disease.

Methods: Coronaviruses are not unknown to the human as other than SARS-CoV-2, at least six additional coronaviruses (SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1) are known that causes mild to severe diseases in human. We have compared the sequences of these seven coronaviruses to identify the key regions which are responsible for pathogenesis.

Results: The genomes of the seven coronaviruses that are known to infect humans differ significantly, especially in the regions of accessory genes.

Conclusion: The analysis of these virus genomes is the key to find out targets for the development of a potent drug or vaccine against COVID-19.

Keywords: SARS-CoV-2, COVID-19, coronavirus, vaccine development, accessory proteins, pathogenesis.

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Article Details

VOLUME: 2
ISSUE: 7
Year: 2021
Published on: 09 December, 2020
Article ID: e250621188925
Pages: 3
DOI: 10.2174/2666796701999201209143320

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