Objective: In January 2020, scientists deciphered the first genome of SARS-CoV-2 that
has created a ravage in the world by infecting over 30 million people worldwide with above 0.95
million deaths as of mid-September 2020. With no potent therapeutics against COVID-19, researchers
around the world are relentlessly working for the development of a vaccine that can ease the
pain the world is suffering today, both in terms of economic and psychological instability. Understanding
the genome of SARS-CoV-2 is essential to decipher the keys that would help scientists to
develop drugs or vaccines to prevent the disease.
Methods: Coronaviruses are not unknown to the human as other than SARS-CoV-2, at least six additional
coronaviruses (SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43, and
HCoV-HKU1) are known that causes mild to severe diseases in human. We have compared the sequences
of these seven coronaviruses to identify the key regions which are responsible for pathogenesis.
Results: The genomes of the seven coronaviruses that are known to infect humans differ significantly,
especially in the regions of accessory genes.
Conclusion: The analysis of these virus genomes is the key to find out targets for the development
of a potent drug or vaccine against COVID-19.