Background: We present the case of a 55-year-old woman, admitted to the Infectious
Disease Department of Policlinico Umberto I, Rome, in mid-March 2020, with suspicion of
Objective: The rRT-PCR was negative, and the following CT scan, performed to exclude false-negative
results and help diagnosis, was inconclusive.
Methods: It was decided to submit the patient to a 99mTc-HMPAO-labelled leukocyte scan.
Results: This exam led to the diagnosis of infective endocarditis.
Conclusion: In the present pandemic scenario, 99mTc-HMPAO-labelled leukocyte scan represents
a reliable imaging technique for differential diagnosis with COVID-19 in patients with confusing
clinical signs, possible false-negative rRT-PCR results, and inconclusive CT scan.