Background: We present the case of a 55-year-old woman, admitted to the Infectious Disease Department of
Policlinico Umberto I, Rome, in mid-March 2020, with suspicion of COVID-19 infection.
Objective: The rRT-PCR was negative and the following CT scan, performed to exclude false-negative results and help diagnosis, was inconclusive.
Methods: It was decided to submit the patient to 99mTc-HMPAO-labelled leukocyte scan.
Results: This exam led to the diagnosis of infective endocarditis.
Conclusion: In the present pandemic scenario, 99mTc-HMPAO-labelled leukocyte scan represents a reliable imaging technique for differential diagnosis with COVID-19 in patients with confusing clinical signs, possible false-negative rRT-PCR
results and inconclusive CT scan.