Eco-friendly and Green Procedure for Iodination of Reactive Aromatics Using PEG 400-I2/HIO3 Combination

Author(s): Amjad Khan Pathan, Pravinkumar Patil, Avinash Shinde, Sainath Zangade*

Journal Name: Current Green Chemistry

Volume 8 , Issue 2 , 2021

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Graphical Abstract:


Background: Iodination of the organic substrate is an important reaction for the synthesis of pharmacologically active molecules.

Methods: In view of these concerns, we reported a convenient procedure for the synthesis of iodo compounds using iodine and iodic acid in PEG-400. We have reported an eco-friendly procedure for the preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400).

Results: The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines, and heterocyclic compounds was carried out using iodine, iodic acid, and PEG-400. The synthesized substituted aromatic iodo compounds were confirmed based on the spectral characterization and mixed melting points.

Conclusion: The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative yields, and purity of iodo products.

Keywords: Iodination, aromatic compounds, iodine, iodic acid, PEG-400, cross-coupling reactions.

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Article Details

Year: 2021
Published on: 08 December, 2020
Page: [166 - 173]
Pages: 8
DOI: 10.2174/2213346107999201208214038
Price: $25

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