Background: Iodination of the organic substrate is an important reaction for the synthesis
of pharmacologically active molecules.
Methods: In view of these concerns, we reported a convenient procedure for the synthesis of iodo
compounds using iodine and iodic acid in PEG-400. We have reported an eco-friendly procedure for
the preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as
polyethylene glycol (PEG-400).
Results: The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols,
amines, and heterocyclic compounds was carried out using iodine, iodic acid, and PEG-400.
The synthesized substituted aromatic iodo compounds were confirmed based on the spectral characterization
and mixed melting points.
Conclusion: The method comprises several advantages such as simple reaction procedure, easy
isolation, quantitative yields, and purity of iodo products.