Molecular Pathways of Interferon-Stimulated Gene 15: Implications in Cancer

Author(s): Angeles C. Tecalco-Cruz*

Journal Name: Current Protein & Peptide Science

Volume 22 , Issue 1 , 2021

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Graphical Abstract:


Human interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokinelike protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in some cancer types.

Keywords: Free ISG15, conjugated ISG15, ISGylation system, cancer, proteins, molecular pathways.

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Article Details

Year: 2021
Published on: 06 April, 2021
Page: [19 - 28]
Pages: 10
DOI: 10.2174/1389203721999201208200747
Price: $65

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