Various neurodegenerative disorders have various molecular origins but some common
molecular mechanisms. In the current scenario, there are very few treatment regimens present for
advanced neurodegenerative diseases. In this context, there is an urgent need for alternate options
in the form of natural compounds with an ameliorating effect on patients. There have been individual
scattered experiments trying to identify potential values of various intracellular metabolites.
Purines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical
reactions, have been long sought as crucial candidates for the same, but there are still many
questions that go unanswered. Some critical functions of these molecules associated with neuromodulation
activities have been identified. They are also known to play a role in foetal neurodevelopment,
but there is a lacuna in understanding their mechanisms. In this review, we have tried to assemble
and identify the importance of purines and pyrimidines, connecting them with the prevalence
of neurodegenerative diseases. The leading cause of this class of diseases is protein misfolding
and the formation of amyloids. A direct correlation between loss of balance in cellular homeostasis
and amyloidosis is yet an unexplored area. This review aims at bringing the current literature
available under one umbrella serving as a foundation for further extensive research in this field of
drug development in neurodegenerative diseases.