Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation

(E-pub Ahead of Print)

Author(s): Iftikhar Haider Naqvi*, Jawad Ahmed, Maliha Salim, Muhammad Ubaid, Farheen Malik, Razna Afzal, Muhammad Moinuddin Ashrafi, Muhammad Arbaz Arshad Khan

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

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Background: Restless leg syndrome (RLS) has been recognized as a typical extra appearance among patients with cirrhosis of liver. RLS prevalence in liver cirrhosis further augments the worsening quality of life which has already been compromised with the disease related complications of cirrhosis itself. Aims: The study was aimed to determine the frequency and severity of Restless Leg Syndrome (RLS) among patients with cirrhosis of liver and to correlate its severity with severity of cirrhosis.

Materials and methods: This prospective cross-sectional study was carried out at Ruth K.M. Pfau Civil Hospital (Karachi, Pakistan) from December 2019 to February 2020. Three hundred and fifteen cirrhotic patients with any etiology were included in the study after informed written consent. Restless leg syndrome with its severity were determined in all cirrhotic patients. For continuous variables, means and medians with standard deviations were calculated, while percentages and proportions were used for discrete variables. Spearman correlation was used to find significance between RLS Severity Score (RSS) and MELD Score. A p value of < 0.05 was considered significant for all analyses.

Results: The frequency of RLS among cirrhotic patients was 38.4%. More than half (54.5%) of the patients had severe RLS. Viral related (hepatitis C and hepatitis B) were the most common cause of cirrhosis of liver (57.8% and 30.8%). Significant difference was found between patients with RLS and without RLS in terms of age (p=0.003), gender (p=0.005), hemoglobin (p=0.00), and serum albumin (p=0.01). No significant association was found between RLS severity score and MELD Score (p=0.693).

Conclusion: Prevalence of RLS is very high among cirrhotic patients but no correlation was found between severity of RLS and severity of cirrhosis. Further studies should be carried out to assess quality of life among cirrhotic RLS patients.

Keywords: Cirrhosis, restless leg syndrome, child-pugh turcotte, model of end-stage liver disease, RLS severity Score (RSS), MELD score.

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(E-pub Ahead of Print)
DOI: 10.2174/1871527319666201208102104

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