Background: The approach for the determination of aminoimidazo-azaarenes (AIAs) is
urgently required due to their mutagenic activity and potential carcinogenicity. For this purpose, a
CdSe/ZnS quantum dots (CdSe/ZnS QDs)-embedded molecularly imprinted silica gel with high
selectivity and sensitivity was successfully prepared and applied to analyze such target.
Methods: Herein, CdSe/ZnS QDs acted as the fluorescent probe, and molecularly imprinted silica
gel as a recognition probe was synthesized on the surface of QDs via sol-gel method. 2-
Aminobenzimidazole, which has a similar structure with AIAs, as well as low cost and low toxicity,
was selected as the dummy template.
Results: The material has a high imprinting factor (IF=6.15); the linear range of CdSe/ZnS@MIP
as a fluorescent sensing material for AIAs is 0.5-20.0 μg L-1 with the limit of detection (LOD) of
0.25 μg L-1 (3σ/s). Moreover, the fluorescent materials have been further applied to determine
AIAs in beef floss and grilled fish fillet with satisfactory recoveries (82.8-110.8 %), and the relative
standard deviation (RSD) is < 5.5%.
Conclusion: The proposed CdSe/ZnS QDs-embedded molecularly imprinted silica gel can be used
to easily and selectively detect AIAs.