Sirtuins are NAD+ dependent enzymes that have a predominant role in neurodegenerative
disorders and also regulate the inflammatory process, protein aggregation, etc. The
relationships between sirtuins with that of the nervous system and neurodegeneration, are widely
studied. Sirtuins have a strong role in metabolic syndrome in mitochondria also. The activities of
sirtuins can be altered by using small molecules that would be developed into drugs and it is
proven that the manipulation of SIRT1 activity influences neurodegenerative disease models. They
are interesting since using small molecules, which would be developed into a drug, it is feasible to
alter the activities of sirtuins. Different functions of sirtuins depend upon their subcellular localization.
In this review paper, we discuss different sirtuins, differential expression of sirtuins, and expression
of sirtuin in the brain and briefly explains Sirtuin3 (SIRT3).