Sirtuin3 in Neurological Disorders

Author(s): Farhath Sherin, S. Gomathy*, Shanish Antony

Journal Name: Current Drug Research Reviews
(Formerly Current Drug Abuse Reviews)

Volume 13 , Issue 2 , 2021


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Abstract:

Sirtuins are NAD+ dependent enzymes that have a predominant role in neurodegenerative disorders and also regulate the inflammatory process, protein aggregation, etc. The relationships between sirtuins with that of the nervous system and neurodegeneration, are widely studied. Sirtuins have a strong role in metabolic syndrome in mitochondria also. The activities of sirtuins can be altered by using small molecules that would be developed into drugs and it is proven that the manipulation of SIRT1 activity influences neurodegenerative disease models. They are interesting since using small molecules, which would be developed into a drug, it is feasible to alter the activities of sirtuins. Different functions of sirtuins depend upon their subcellular localization. In this review paper, we discuss different sirtuins, differential expression of sirtuins, and expression of sirtuin in the brain and briefly explains Sirtuin3 (SIRT3).

Keywords: Sirtuins, SIRT3, mitochondria, Parkinson’s disease, Alzheimer's disease, Huntington's disease.

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Article Details

VOLUME: 13
ISSUE: 2
Year: 2021
Published on: 07 December, 2020
Page: [140 - 147]
Pages: 8
DOI: 10.2174/2589977512666201207200626
Price: $65

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