Background: For thousands of years, natural food products have been used as a
medicine for treating diseases that affect the human body, including diabetes mellitus (DM). Lately,
several investigations have been performed on the flavonoid derivatives of plant origin, and
their biological activity has been extensively studied.
Methods: Given our need to know more mechanisms for treating DM, we performed a thorough research
review on treating diabetes mellitus based on flavonoids, their therapeutic potential, and biological
Results: Flavonoids reduce complications in addition to their vital role as effective supplements for
preventing diabetes mellitus by regulating glucose metabolism, lipid profile, liver enzyme activity,
a protein kinase inhibitor, PPAR, and AMPK with NF-κB.
Conclusion: The articles that we reviewed showed the positive role of flavonoids, which in a certain
way reduce diabetes, but their side effects still need to be studied further.This review is focused
on describing the different types of dietary flavonoids along with their mechanisms of reducing
blood glucose and enhancing insulin sensitivity, as well as their side effects.