The care of the individual with diabetic foot disease (DFD) represents a significant challenge. In addition
to the primary foot pathology, individuals with DFD are frequently compromised by multiple co-existent
medical complications. Successful management of DFD, therefore requires simultaneous addressal of these issues
alongside high-quality foot care. We explore the pharmacological treatments in DFD with an emphasis on
the emerging putative technologies centred on addressing the pathobiology of wound healing but also discuss
developments in infection control, Charcot neuroarthropathy, cardiovascular and diabetes care. Many of these
will have a significant impact on future treatment paradigms and how we amalgamate these novel technologies
may help shape the standard of care in DFD hereafter. However, there is a need for better quality of evidence
and cost-effectiveness data prior to widespread adoption into routine care is considered.
Keywords: Diabetic foot disease, diabetic foot ulcer, wound healing, cardiovascular risk, glycaemic control, charcot foot, pharmacotherapy
in diabetic foot.
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