Role of Extracellular Vesicles in Glioma Progression: Deciphering Cellular Biological Processes to Clinical Applications

Author(s): Rashmi Rana*, Shikha Joon, Kirti Chauhan, Vaishnavi Rathi, Nirmal Kumar Ganguly, Chandni Kumari, Dharmendra Kumar Yadav*

Journal Name: Current Topics in Medicinal Chemistry

Volume 21 , Issue 8 , 2021


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Abstract:

Glioma predominantly targets glial cells in the brain and spinal cord. There are grade I, II, III, and IV gliomas with anaplastic astrocytoma and glioblastoma multiforme as the most severe forms of the disease. Current diagnostic methods are limited in their data acquisition and interpretation, markedly affecting treatment modalities, and patient outcomes. Circulating extracellular vesicles (EVs) or “magic bullets” contain bioactive signature molecules such as DNA, RNA, proteins, lipids, and metabolites. These secretory “smart probes” participate in myriad cellular activities, including glioma progression. EVs are released by all cell populations and may serve as novel diagnostic biomarkers and efficient nano-vehicles in the targeted delivery of encapsulated therapeutics. The present review describes the potential of EV-based biomarkers for glioma management.

Keywords: Biomarker, Diagnostic, Extracellular vesicle, Glioma, Therapeutic, Smart probes.

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Article Details

VOLUME: 21
ISSUE: 8
Year: 2021
Page: [696 - 704]
Pages: 9
DOI: 10.2174/1568026620666201207100139
Price: $95

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