Background: Mucoadhesive polymers play a critical role in controlled-release tablets for buccal drug
Objective: This research aimed to investigate the characterization and mechanisms of solid lipid particle-based
tablets with different mucoadhesive polymers for buccal delivery.
Methods: Prednisolone (PSL)-loaded Solid Lipid Particles (SLPs) were conventionally prepared by
ultrasonication. The freeze-drying method was used to convert the SLP suspension into a solid dosage form for
buccal delivery by using mucoadhesive polymers.
Results: All formulations showed over 80% drug release after 6h, which followed immediate and sustained
release patterns depending on the SLP type. However, the different polymers in the formulations resulted in
different mucoadhesion times and drug release and drug permeability profiles. HPMC 4000 showed higher drug
permeation (3327 μg vs. 2589 μg after 6h) but a shorter mucoadhesion time than Carbopol (197 min vs. 361 min).
In addition, surface morphology, swelling and erosion, particle size and zeta potential were also noted for the
different mechanisms for buccal tablet design with different controlled release profiles.
Conclusion: The results of this work indicate a good strategy for the selection of mucoadhesive polymers for
SLP-based tablets in improving the bioavailability of poorly water-soluble drugs.