Synthetic and Semi-synthetic Drugs as a Promising Therapeutic Option for the Treatment of COVID-19

Author(s): Ekta Shirbhate, Preeti Patel, Vijay K Patel, Ravichandran Veerasamy, Prabodh C Sharma, Barij N Sinha, Harish Rajak*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 8 , 2021

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Graphical Abstract:


The novel coronavirus disease-19 (COVID-19) is a global pandemic that emerged from Wuhan, China, and has spread all around the world, affecting 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 updates of August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine exists. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID- 19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in clinical uses or studies on COVID-19 and also focuses on the mode of action of drugs being repositioned against COVID-19.

Keywords: Clinical trials, coronavirus, COVID-19, pathogenesis, SARS-CoV-2, synthetic and semi-synthetic antiviral drugs.

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Article Details

Year: 2021
Published on: 04 December, 2020
Page: [1004 - 1016]
Pages: 13
DOI: 10.2174/1389557520666201204162103
Price: $65

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PDF: 20