Techniques of Mucilage and Gum Modification and their Effect on Hydrophilicity and Drug Release

Author(s): Rishabha Malviya*, Vandana Tyagi, Dharmendra Singh

Journal Name: Recent Patents on Drug Delivery & Formulation
Continued as Recent Advances in Drug Delivery and Formulation

Volume 14 , Issue 3 , 2020


Graphical Abstract:


Abstract:

Aim: The manuscript aims to describe the techniques of modification of gums and mucilages and their effect on hydrophilicity and drug release.

Discussion: The interest is increased in the fields of polymers which are obtained from natural origin and used in the preparation of pharmaceuticals. Mucilage and gum are natural materials widely used in the preparation of novel dosage and conventional dosage forms. They are used in the pharmaceutical industry for various purposes like suspending, emulsifying, bio-adhesive, binding, matrix-forming, extended release and controlled release agent. Gum and mucilage are biodegradable, less toxic, cheap and easily available. Moreover, mucilage and gum can be changed to acquire tailored materials for the delivery of drugs and allow them to compete with commercially available synthetic products. These polysaccharides have unique swellability in an aqueous medium that can exert a retardant effect on drug release or act as a super disintegrant, depending on the concentration utilized in the preparation. Drug release mechanism from hydrophilic matrices consisting of gums and mucilages is based on solvent penetration-induced polymer relaxation, diffusion of entrapped drug followed by degradation or erosion of the matrix.

Conclusion: The present manuscript highlights the advantages, modifications of gum and mucilage, their effects on hydrophilicity and drug release as well as aspects of the natural gums which can be assumed to be bifunctional excipient because of their concentration-dependent effect on drug release and their high degree of swellability.

Keywords: Polysaccharides, gums and mucilages, hydrophilicity, modified gums, polysaccharide modification, drug release.

[1]
Singh R, Sharma PK, Dhakad P. Methods and evaluation parameter of sustained release muco-adhesive microsphere. Adv Biol Res (Faisalabad) 2014; 8(5): 201-6.
[2]
Pathak K, Malviya R. Polysaccharides for drug delivery in Advanced applications of polysaccharides and their composites Material research foundations 2020; 73: 27-64.
[3]
Malviya R, Sharma PK, Dubey SK. Stability facilitation of nanoparticles prepared by ultrasound assisted solvent-antisolvent method: Effect of neem gum, acrylamide grafted neem gum and carboxymethylated neem gum over size, morphology and drug release. Mater Sci Eng C 2018; 91: 772-84.
[http://dx.doi.org/10.1016/j.msec.2018.06.013] [PMID: 30033312]
[4]
Arsul VA, Lahoti SR. Natural polysaccharides as pharmaceutical excipients. World J Pharm Res 2014; 3: 3776-90.
[5]
Shah DP, Prajapati VD, Jain VC. Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian J Pharm Sci 2009; 4(5): 309-32.
[6]
Beneke CE, Viljoen AM, Hamman JH. Polymeric plant-derived excipients in drug delivery. Molecules 2009; 14(7): 2602-20.
[http://dx.doi.org/10.3390/molecules14072602] [PMID: 19633627]
[7]
Pandey R, Khuller GK. Polymer based drug delivery systems for mycobacterial infections. Curr Drug Deliv 2004; 1(3): 195-201.
[http://dx.doi.org/10.2174/1567201043334669] [PMID: 16305383]
[8]
Malviya R, Sharma PK, Dubey SK. Modification of polysaccharides: Pharmaceutical and tissue engineering applications with commercial utility (patents). Mater Sci Eng C 2016; 68: 929-38.
[http://dx.doi.org/10.1016/j.msec.2016.06.093] [PMID: 27524095]
[9]
Geetha B, Gowda KP, Kulkarni GT. Microwave assisted fast extraction of mucilages and pectins. Indian J Pharm Educ Res 2009; 43: 260-5.
[10]
Kumar R, Sharma A. Grafting modification of the polysaccharide by the use of microwave irradiation- A Review. Int J Adv Pharm Res 2012; 2: 45-53.
[11]
Sumardiono S, Riska L, Jos B, Pudjiastuti I. Effect of esterification on cassava starch: physicochemical properties and expansion ability. Reaktor 2019; 19(1): 34-41.
[http://dx.doi.org/10.14710/reaktor.19.1.34-41]
[12]
Khan MA, Bhattacharia SK, Kader MA. Preparation and characterzaton of Ultra Violet (UV) radiaton cured bio-degradable films of sago starch/PVA blend. Carbohydr Polym 2006; 63: 500-6.
[http://dx.doi.org/10.1016/j.carbpol.2005.10.019]
[13]
Reddy N, Reddy R, Jiang Q. Crosslinking biopolymers for biomedical applications. Trends Biotechnol 2015; 33(6): 362-9.
[http://dx.doi.org/10.1016/j.tibtech.2015.03.008] [PMID: 25887334]
[14]
Malviya R, Sharma PK, Dubey SK. Modification & Applications of Polysaccharides. Lap Lambert Academic Publishing 2016.
[15]
Rana V, Raia P, Tiwarya AK, Singh RS, Kennedy JF, Knill CJ. Modified gums: Approaches and applications in drug delivery. Carbohydr Polym 2011; 83: 1031-47.
[http://dx.doi.org/10.1016/j.carbpol.2010.09.010]
[16]
Prajapati VD, Jani GK, Moradiya NG, Randeria NP. Pharmaceutical applications of various natural gums, mucilages and their modified forms. Carbohydr Polym 2013; 92(2): 1685-99.
[http://dx.doi.org/10.1016/j.carbpol.2012.11.021] [PMID: 23399207]
[17]
Gupta S, Sharma P, Soni PL. Chemical modification of Cassia occidentalis seed gum: Carbamoylethylation. Carbohydr Polym 2005; 59: 501-6.
[http://dx.doi.org/10.1016/j.carbpol.2004.11.010]
[18]
Bahulkar SS, Munot NM, Surwase SS. Synthesis, characterization of thiolated karaya gum and evaluation of effect of pH on its mucoadhesive and sustained release properties. Carbohydr Polym 2015; 130: 183-90.
[http://dx.doi.org/10.1016/j.carbpol.2015.04.064] [PMID: 26076615]
[19]
Subrahmanyam PJ. Design and development of guar gum and borax crosslinked guar gum matrix tablets of theophylline for colon specific drug. J Chem Pharm Res 2012; 4(2): 1052-60.
[20]
Mohammed KG. Modified starch and its potentials as excipient in pharmaceutical formulations. NAPDD 2017; 1(1): 1-4.
[21]
Malviya R, Sharma PK, Dubey SK. Antioxidant potential and emulsifying properties of kheri (Acacia chundra, Mimosaceae) gum polysaccharide. Marmara Pharm J 2017; 21(3): 701-6.
[http://dx.doi.org/10.12991/marupj.323594]
[22]
Bhosale RR, Osmani RAM, Moin A. Review on natural polysaccharide based particulate drug delivery systems: An inimitable tactic in novel drug delivery systems. Int J Curr Pharm Rev Res 2015; 6: 8-21.
[23]
Kulkarni AD, Joshi AA, Patil CL, et al. Xyloglucan: A functional biomacromolecule for drug delivery applications Int J Biol Macromol 2017; 104(Pt A): 799-812.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.06.088] [PMID: 28648637]
[24]
Singh B, Chauhan GS, Kumar S. Synthesis characterization and swelling responses of pH sensitive psyllium and polyacrylamide based hydrogels for the use in drug delivery. Carbohydr Polym 2007; 67: 190-200.
[http://dx.doi.org/10.1016/j.carbpol.2006.05.006]
[25]
Farooq U, Malviya R, Sharma PK. Extraction and characterization of okra mucilage as pharmaceutical excipient. Academic Journal of Plant Sciences 2013; 6(4): 168-72.
[26]
Mishra RK, Datt M, Pal K, Banthia AK. Preparation and characterization of amidated pectin based hydrogels for drug delivery system. J Mater Sci Mater Med 2008; 19(6): 2275-80.
[http://dx.doi.org/10.1007/s10856-007-3310-4] [PMID: 18058200]
[27]
Builders PF, Arhewoh MI. Pharmaceutical applications of native starch in conventional drug delivery. Starke 2016; 68(9-10): 864-73.
[http://dx.doi.org/10.1002/star.201500337]
[28]
Conceição J, Adeoye O, Cabral-Marques HM, Lobo JMS. Cyclodextrins as excipients in tablet formulations. Drug Discov Today 2018; 23(6): 1274-84.
[http://dx.doi.org/10.1016/j.drudis.2018.04.009] [PMID: 29689302]
[29]
Li R, Jia X, Wang Y, Li Y, Cheng Y. The effects of extrusion processing on rheological and physicochemical properties of sesbania gum. Food Hydrocoll 2019; 90: 35-40.
[http://dx.doi.org/10.1016/j.foodhyd.2018.11.048]
[30]
Fu Y, Kao WJ. Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems. Expert Opin Drug Deliv 2010; 7(4): 429-44.
[http://dx.doi.org/10.1517/17425241003602259] [PMID: 20331353]
[31]
Rasul A, Iqbal M, Murtaza G, et al. Design, development and in-vitro evaluation of metoprolol tartrate tablets containing xanthan-tragacanth. Acta Pol Pharm 2010; 67(5): 517-22.
[PMID: 20873420]
[32]
Ghasemiyeh P, Mohammadi-Samani S. Hydrogels as drug delivery systems; pros and cons. Trends Pharmacol Sci 2019; 5(1): 7-24.
[33]
Dubey D, Malviya R, Kumar Sharma P. Mathematical modelling and release behaviour of drug. Drug Deliv Lett 2014; 4(3): 254-68.
[http://dx.doi.org/10.2174/2210303104666141001002404]
[34]
Sankalia JM, Sankalia MG, Mashru RC. Drug release and swelling kinetics of directly compressed glipizide sustained-release matrices: establishment of level A IVIVC. J Control Release 2008; 129(1): 49-58.
[http://dx.doi.org/10.1016/j.jconrel.2008.03.016] [PMID: 18456362]
[35]
Rajesh KS, Venkataraju MP, Gowda DV. Effect of hydrophilic natural gums in formulation of oral-controlled release matrix tablets of propranolol hydrochloride. Pak J Pharm Sci 2009; 22(2): 211-9.
[PMID: 19339235]
[36]
Malviya R, Srivastava P. Preparation, characterization and application of chitosan-alginate based polyelectrolyte complex as fast disintegrating drug delivery carrier. Polim Med 2011; 41(3): 45-54.
[PMID: 22046827]
[37]
Malviya R, Sharma PK, Dubey SK. Microwave-assisted preparation of biodegradable, hemocompatible, and antimicrobial neem gum–grafted poly (acrylamide) hydrogel using (3) 2 factorial design. Emerg Mat 2019; 2(1): 95-112.
[http://dx.doi.org/10.1007/s42247-019-00022-y]
[38]
Cherstvy AG, Thapa S, Wagner CE, Metzler R. Non-Gaussian, non-ergodic, and non-Fickian diffusion of tracers in mucin hydrogels. Soft Mater 2019; 15(12): 2526-51.
[http://dx.doi.org/10.1039/C8SM02096E] [PMID: 30734041]
[39]
Labuza TP, Altunakar B. Diffusion and sorption kinetics of water in foods Water activity in foods: Fundament and app 2020; 287-309.
[40]
Lin G. Describe NMR relaxation by anomalous rotational or translational diffusion. Commun Nonlinear Sci Numer Simul 2019; 72: 232-9.
[http://dx.doi.org/10.1016/j.cnsns.2018.12.017]
[41]
Danyuo Y, Ani CJ, Salifu AA, et al. Anomalous release kinetics of prodigiosin from poly-N-Isopropyl-Acrylamid based hydrogels for the treatment of triple negative breast cancer. Sci Rep 2019; 9(1): 3862.
[http://dx.doi.org/10.1038/s41598-019-39578-4] [PMID: 30846795]
[42]
Pinel A. Process for manufacturing gum or mucilage from locustbeans. US 1,106,335, 1914.
[43]
Frisch N. Modified locust bean gum, solution thereof, and process 160 for making a locust bean gum solution. US 2,644,765, 1953.
[44]
Blumenthal A. Preparation of modified products of galactomannanes, polyuronic acids and similar high-molecular natural substances. US 3,300,473, 1967.
[45]
Steven A. Method for the manufacture of mustard mucilage. US 165 3,878,195, 1975.
[46]
Guo H, Chen J, Su D, Ashton P. Bioerodibe sustained release drug delivery systems. US 8815284B2, 2014.
[47]
Gulati M, Singh S, Duggal S, Satyakam R, Sharma M. Improved oral targeted drug delivery system. WO 2012035561A2, 2012.
[48]
Kim YH, Kim JK. Low molecular weight methyl cellulose based parenteral drug delivery system. US 9700630B2, 2017.
[49]
Sintov A, Rubinstein A. Colonic drug delivery system. US 5525634A, 1996.
[50]
Baozhen S. Natural porous polymer beads, the preparation and application thereof. CN 1485094A, 2004.


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Article Details

VOLUME: 14
ISSUE: 3
Year: 2020
Page: [214 - 222]
Pages: 9
DOI: 10.2174/1872211314666201204160641
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