The Outbreak of Coronavirus Disease 2019 (COVID-19) and its Manifestation

(E-pub Ahead of Print)

Author(s): Bikash Debnath, Waikhom Somraj Singh, Kuntal Manna*

Journal Name: Coronaviruses
The World's First International Journal Dedicated to Coronaviruses

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The coronavirus disease 2019 (COVID-19) first outbreak in Wuhan, China, and the infection is intense worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19. The World Health Organization (WHO) confirmed total deaths had noted 4.20% globally (March 21, 2020). Between the intervals of four months (July 21, 2020), confirmed total deaths had recorded 4.17%, globally. In India, 909 confirmed cases and 19 deaths were reported by Health and Family Welfare, Government of India, March 28, 2020. Between the intervals of 123 days In India, 1638870 confirmed cases and 35684 deaths. COVID-19 can potentially spread from person to person through direct contact or respiratory droplets from coughing and sneezing. The most common symptoms are fever, dry cough, difficulty in breathing, and fatigue. A pregnant mother with COVID-19 has fewer chances to transfer this infection of her newborn babies. Children have less affected than an adult. A specific antiviral drug or vaccine has not been developed to cure the disease. Chloroquine, hydroxychloroquine, lopinavir, ritonavir, nafamostat, nitazoxanide, and remdesivir have effective drugs to treat COVID-19. Many vaccine candidates are under pre-clinical and clinical studies. In this review, we highlight the epidemiology, sign-symptoms, pathogenesis, mode of transmission, and effects of a pregnant mother with newborns, children, prevention, and drugs affective to COVID-19.

Keywords: COVID-19, epidemiology, SARS-CoV-2, prevention, pregnancy and newborns, affective dugs. COVID-19, epidemiology, SARS-CoV-2, prevention, pregnancy and newborns, affective dugs.

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(E-pub Ahead of Print)
DOI: 10.2174/2666796701999201204121813

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