Therapeutic Options for the Treatment of 2019-Novel Coronavirus in India: A Systematic Review

(E-pub Ahead of Print)

Author(s): Pratyay Kumar Pahari, Sonal Vyas, Shahbaz Aman, Uday Singh, Kusheswar Prasad Singh, Rohit Tiwari, Meenakshi Dhanawat*

Journal Name: Coronaviruses
The World's First International Journal Dedicated to Coronaviruses

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Purpose: As of from 30 Jan to 31 May, 2020, more than 182,143 confirmed cases reported in India along with 86,984 recovered cases and 5164 deceased cases of COVID-19. More than 53 countries are also affected with this pandemic virus. However, the lack of specific drugs to prevent/treat this pandemic disease is a major problem at this current scenario. In this regard, this systemic review was conducted to identify the therapeutic approaches and researches which are ongoing in India against COVID-19.

Methods: We had screened Google Scholar database with the keywords nCoV, corona virus in India, effect of SARS-CoV-2 in India, 2019-nCoV, treatment pattern in India for nCoV and therapy used to treat nCoV in India. In the final review we had included a total of 49 articles.

Results: As a result we had found that Indian Council of Medical Research and NIH have given a standard guideline of Hydroxychloroquine and other antiviral drugs for nCoV, and also there are various researches going on related to nCoV treatment like, chemicals from natural products, herbs and spices commonly used in India, combination therapy of lopinavir and ritonavir, ultra-violet radiation therapy, molecular dynamic (MD) simulations of molecules for vaccine preparation, Convalescent plasma transfusion (CPT) therapy and many more.

Conclusions: New drugs and therapy are in the premature stage for this hazardous pandemic. We need more time to gain the detailed knowledge of the life cycle of the nCoV, which can speed up the drug/vaccine development process against nCoV.

Keywords: nCoV, Novel coronavirus, Treatment of nCoV, SARS-CoV-2, ICMR, NIHnCoV, Novel coronavirus, Treatment of nCoV, SARS-CoV-2, ICMR, NIH

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(E-pub Ahead of Print)
DOI: 10.2174/2666796701999201204115545

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