Lymphatic system is the secondary circulation system of the human body after the systemic circulation.
Various problems, including the first-pass metabolism through oral administration of medicines, can be
resolved by lymphatic targeting. Lymphatic absorption has been explored in detail, and studies reveal the improved
bioavailability of medicines. In the case of cancer, AIDS, and various other health problems, lymphatic
targeting has been focused on due to the fact that lymph nodes are involved greatly in tumor metastasis. This
article reviews lymphatic absorption and its exploration in the treatment of various health problems. The physiology
of the lymphatic system, the mechanisms of absorption, and the various formulation systems suitable for
lymphatic absorption have been discussed. Some recent novel approaches like hydrodynamically driven device
(HDD) and carbon nanotubes for lymphatic delivery have also been appraised.