Lymphatic Drug Transport and Associated Drug Delivery Technologies: A Comprehensive Review

Author(s): Manjot S. Punjabi, Anup Naha*, Disha Shetty, Usha Y. Nayak

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 17 , 2021


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Abstract:

Lymphatic system is the secondary circulation system of the human body after the systemic circulation. Various problems, including the first-pass metabolism through oral administration of medicines, can be resolved by lymphatic targeting. Lymphatic absorption has been explored in detail, and studies reveal the improved bioavailability of medicines. In the case of cancer, AIDS, and various other health problems, lymphatic targeting has been focused on due to the fact that lymph nodes are involved greatly in tumor metastasis. This article reviews lymphatic absorption and its exploration in the treatment of various health problems. The physiology of the lymphatic system, the mechanisms of absorption, and the various formulation systems suitable for lymphatic absorption have been discussed. Some recent novel approaches like hydrodynamically driven device (HDD) and carbon nanotubes for lymphatic delivery have also been appraised.

Keywords: Lymphatic system, drug delivery, absorption, bioavailability, lymph nodes, drug target.

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Article Details

VOLUME: 27
ISSUE: 17
Year: 2021
Published on: 03 December, 2020
Page: [1992 - 1998]
Pages: 7
DOI: 10.2174/1381612826999201203214247
Price: $65

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