Background: The thiocyanation of indoles is a direct way for carbon-sulfur bond formation to access
3-thiocyanato-indoles. 3-thiocyanato-indoles exhibit potent biological and pharmacological activities and also
serve as building blocks to synthesize many biologically active sulfur-containing indole derivatives.
Objective: The aim of this review is to highlight different approaches for the thiocyanation of indoles focusing on
its scope and mechanism.
Conclusion: In this review, we have summarized various methods for the thiocyanation of indoles. Selection of
new methods for the preparation of 3-thiocyanato-indoles will be done. The mechanistic aspects and significance
of the methods are also briefly discussed.