Diverse Thiophenes as Scaffolds in Anti-cancer Drug Development: A Concise Review

Author(s): Neha V. Bhilare*, Pratibha B. Auti, Vinayak S. Marulkar, Vilas J. Pise

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 21 , Issue 2 , 2021


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Abstract:

Thiophenes are one of the abundantly found heterocyclic ring systems in many biologically active compounds. Moreover, various substituted thiophenes exert numerous pharmacological actions on account of their isosteric resemblance with compounds of natural origin, thus rendering them with diverse actions like antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, antiallergic, hypotensives, etc. In this review, we specifically explore the chemotherapeutic potential of a variety of structures consisting of thiophene scaffolds as prospective anticancer agents.

Keywords: Thiophenes, anticancer, structure activity relationship, mechanism of action, anti-tumor, cytotoxic.

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VOLUME: 21
ISSUE: 2
Year: 2021
Published on: 01 December, 2020
Page: [217 - 232]
Pages: 16
DOI: 10.2174/1389557520666201202113333
Price: $65

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