Background: A number of studies have proposed that lncRNA XIST plays a role in the development
and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients.
The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC.
Methods: In this review, relevant researches involving the relationship between XIST and NSCLC are collected
through systematic retrieval of PubMed.
Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence
has shown that XIST plays a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity
of NSCLC cells. XIST mainly functions as a ceRNA in the NSCLC process, while XIST also functions
at transcriptional levels.
Conclusion: LncRNA XIST has the potential to become a novel biomolecular marker of NSCLC and a therapeutic
target for NSCLC.