XIST: A Meaningful Long Noncoding RNA in NSCLC Process

Author(s): Yujie Shen, Yexiang Lin, Kai Liu, Jinlan Chen, Juanjuan Zhong, Yisong Gao, Chengfu Yuan*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 11 , 2021


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Abstract:

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC.

Methods: In this review, relevant researches involving the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed.

Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST plays a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in the NSCLC process, while XIST also functions at transcriptional levels.

Conclusion: LncRNA XIST has the potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

Keywords: XIST, NSCLC, therapeutic target, biomolecular marker, noncoding, RNA.

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Article Details

VOLUME: 27
ISSUE: 11
Year: 2021
Published on: 01 December, 2020
Page: [1407 - 1417]
Pages: 11
DOI: 10.2174/1381612826999201202102413
Price: $65

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