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General Review Article

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

Author(s): Yujie Shen, Yexiang Lin, Kai Liu, Jinlan Chen, Juanjuan Zhong, Yisong Gao and Chengfu Yuan*

Volume 27, Issue 11, 2021

Published on: 02 December, 2020

Page: [1407 - 1417] Pages: 11

DOI: 10.2174/1381612826999201202102413

Price: $65

Abstract

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC.

Methods: In this review, relevant researches involving the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed.

Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST plays a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in the NSCLC process, while XIST also functions at transcriptional levels.

Conclusion: LncRNA XIST has the potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

Keywords: XIST, NSCLC, therapeutic target, biomolecular marker, noncoding, RNA.

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