Burns, mechanical injuries, skin defects, poor wound healing and scars caused by chronic
diseases are serious clinical issues that affect millions of people around the world. Hyaluronic
acid (HA) is one of the main components of extracellular matrix, which is widely distributed in human
body. Because of its unique physical and chemical properties and diversity of physiological
functions, hyaluronic acid is widely used in tissue engineering and regenerative medicine. This paper
reviews the application of HA and HA based scaffolds in the regeneration and repair of skin tissue,
as well as the application of HA in the fields of skin filler, wound healing, beauty, etc.