An Exposition of 11C and 18F Radiotracers Synthesis for PET Imaging

Author(s): Priya Saxena, Tarique Mahmood*, Manish Dixit, Sanjay Gambhir, Farogh Ahsan

Journal Name: Current Radiopharmaceuticals

Volume 14 , Issue 2 , 2021

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Graphical Abstract:


The development of new radiolabeled Positron emission tomography tracers has been extensively utilized to access the increasing diversity in the research process and to facilitate the development in research methodology, clinical usage of drug discovery and patient care. Recent advances in radiochemistry, as well as the latest techniques in automated radio-synthesizer, have encouraged and challenged the radiochemists to produce the routinely developed radiotracers. Various radionuclides like 18F, 11C, 15O, 13N 99mTc, 131I, 124I and 64Cu are used for incorporating into different chemical scaffolds; among them, 18F and 11C tagged radiotracers are mostly explored such as 11C-Methionine, 11C-Choline, 18F-FDG, 18F-FLT, and 18F-FES. This review is focused on the development of radiochemistry routes to synthesize different radiotracers of 11C and 18F for clinical studies.

Keywords: Radionuclide, radiolabeled, positron emission tomography, imaging, radiotracer, radiochemistry.

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Article Details

Year: 2021
Published on: 30 November, 2020
Page: [92 - 100]
Pages: 9
DOI: 10.2174/1874471013666201201095631
Price: $65

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PDF: 46