Title:The Effects of Glucagon-Like Peptide Type 1 (GLP-1) and its Analogues in Adipose Tissue: Is there a way to Thermogenesis?
VOLUME: 21 ISSUE: 7
Author(s):Iurii Stafeev*, Ekaterina Sorkina, Ekaterina Koksharova, Tatevik Tumanyan, Igor Sklyanik, Mikhail Menshikov, Alexandr Mayorov, Yelena Parfyonova and Marina Shestakova
Affiliation:National Medical Research Center for Cardiology, Moscow, Endocrinology Research Centre, Moscow, Endocrinology Research Centre, Moscow, Endocrinology Research Centre, Moscow, Endocrinology Research Centre, Moscow, National Medical Research Center for Cardiology, Moscow, Endocrinology Research Centre, Moscow, National Medical Research Center for Cardiology, Moscow, Endocrinology Research Centre, Moscow
Keywords:Glucagon-like peptide type 1, incretins, fat beiging, insulin resistance, type 2 diabetes, glucagon.
Abstract:Obesity is a global problem and the most common metabolic disorder leading
to many associated diseases, such as arterial hypertension, ischemic heart disease,
type 2 diabetes, certain types of cancer, impaired lipid and uric acid metabolism. The
prevalence of obesity has risen globally in the past four decades in both children and
adults, and it accounts for the rapid increase in the prevalence of diabetes. Currently,
the study of thermogenic tissues, brown and beige adipose tissues, is of extreme value
from the point of view of therapeutic potential for obesity and its associated diseases. An
analogue of the glucagon-like peptide-1 (GLP-1) liraglutide, used in the treatment of type
2 diabetes, has been proven to have a positive effect on weight loss through appetite
suppression. However, this mechanism of weight loss is not the only one involved. This
article discusses the main molecular and cellular mechanisms of adipogenesis, as well
as the effect of GLP-1 and its analogues, in particular liraglutide on this process through
various transcription factors, signaling pathways, and hormones, including brown and
beige adipose tissue. Also, the twincretins have had a positive effect on insulin
resistance and fat beiging activation. The results of numerous studies have helped us to
better understand the peripheral mechanisms of lipid metabolism regulation, and have
demonstrated the effectiveness of GLP-1 analogues for the treatment of diabetes and
obesity.
