Electromagnetic Field in Alzheimer’s Disease: A Literature Review of Recent Preclinical and Clinical Studies

Author(s): Reem H.M.A. Ahmad, Marc Fakhoury*, Nada Lawand*

Journal Name: Current Alzheimer Research

Volume 17 , Issue 11 , 2020

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Abstract:

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive loss of neurons leading to cognitive and memory decay. The main signs of AD include the irregular extracellular accumulation of amyloid-beta (Aβ) protein in the brain and the hyper-phosphorylation of tau protein inside neurons. Changes in Aβ expression or aggregation are considered key factors in the pathophysiology of sporadic and early-onset AD and correlate with the cognitive decline seen in patients with AD. Despite decades of research, current approaches in the treatment of AD are only symptomatic in nature and are not effective in slowing or reversing the course of the disease. Encouragingly, recent evidence revealed that exposure to electromagnetic fields (EMF) can delay the development of AD and improve memory. This review paper discusses findings from in vitro and in vivo studies that investigate the link between EMF and AD at the cellular and behavioural level, and highlights the potential benefits of EMF as an innovative approach for the treatment of AD.

Keywords: Alzheimer's disease, amyloid-beta, electromagnetic field, animal studies, human studies, neurons.

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Article Details

VOLUME: 17
ISSUE: 11
Year: 2020
Published on: 21 January, 2021
Page: [1001 - 1012]
Pages: 12
DOI: 10.2174/1567205017666201130085853
Price: $65

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