A Review on the Current Principles of Antibiotic Therapy for Diabetic Foot Infection

Author(s): Sainath Prasanna Bharathi, Sathesh Kumar Sukumaran*

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Volume 21 , Issue 5 , 2021

Article ID: e270421188440
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Graphical Abstract:


Foot infections, being one of the major complications, account for nearly 15% of people with diabetes, and increase their risk for amputation in lower extremities. Though various factors contribute to the development of diabetic foot infection, poor glycemic control poses a greater risk paving the way for a number of micro-organisms to colonize the wound.

In order to restore the lost granulation tissue at the ulcer site, the prime aim should not only be attaining glycemic control but also must focus on performing culture by clinically differentiating the stage of infection as well as to manage or control the infection by selecting a rational empiric antibiotic regimen, amidst the uncertainty that exists in choosing best antimicrobial therapy in emerging multi-drug resistance worldwide.

This review mainly analyzes that although among the existence of various undefined microbiome being prevalent in causing diabetic foot infections, how the current trend of antibiotics in use aids in treating foot infections in diabetes.

Keywords: Diabetic foot infections, matrix metallo-proteinases, wagner classification, methicillin resistant Staphylococcusaureus, antimicrobial therapy, microbiome.

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Article Details

Year: 2021
Published on: 26 November, 2020
Article ID: e270421188440
Pages: 10
DOI: 10.2174/1871526520999201126203738
Price: $65

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PDF: 106