Background: Azithromycin has been considered as a possible therapeutic agent for
COVID-19 patients. However, there is limited data on its efficacy.
Case Presentation: We describe three patients diagnosed with COVID-19 who did not respond to
the initial treatment but improved dramatically upon adding azithromycin with a successful outcome.
Conclusion: We have presented evidence of the potential beneficial effect of the azithromycin in
the treatment of patients with COVID-19 in three different clinical settings. More evidence is needed
regarding the microbiological data, safety, and efficacy of this medication in the management of