Background: Ehlers-Danlos Syndromes (EDS) comprise a group of heterogeneous hereditary
connective tissue disorders [1, 2]. Psychiatric disorders such as depression, anxiety, panic
disorder, agoraphobia, schizophrenia, neurodevelopmental disorders, personality disorder, eating
disorders, substance misuse and interpersonal issues have been reported in the literature to be associated
with EDS [1-3].
Objectives: The case of a 15-year old male who was hospitalized after a suicide attempt by gunshot,
who was discovered to have symptoms suggestive of EDS, is presented in this paper along with the
results of a literature search of psychiatric manifestations of EDS in children and adolescents.
Methods: Literature review was conducted on the UpToDate website on March 11, 2020 to review
symptoms of Ehlers-Danlos Syndrome for the purpose of preliminary diagnosis of this patient. Additional
literature search was conducted on PubMed on 4/2/20 at 12:10 P.M. and on 4/9/20 at 10:51
P.M. and on the search engine Google on 4/2/20 at 12:25 P.M. On May 11, 2020 at 2 P.M., another
web search was conducted with a review of 6 different websites pertaining to Ehlers-Danlos
Results: A systematic review of psychiatric manifestations of Ehlers-Danlos Syndromes revealed a
strong incidence of psychiatric symptoms.
Conclusion: Our patient’s psychiatric symptoms of depression, suicidal ideations, anxiety and social
and educational struggles may have been at least partially due to chronic pain- abdominal,
headache and musculoskeletal, and social ostracization associated with Ehlers-Danlos Syndrome.
Education regarding this illness helped our patient’s recovery as he came to understand why he was
so “odd” and the cause of his multisystemic chronic pain.