Diabetes mellitus (DM) and peripheral artery disease (PAD) are two clinical entities closely associated.
They share many pathophysiological pathways such as inflammation, endothelial dysfunction, oxidative
stress and pro-coagulative unbalance. Emerging data focusing on agents targeting these pathways may be promising.
Moreover, due to the increased cardiovascular risk, there is a growing interest in cardiovascular and
“pleiotropic” effects of novel glucose lowering drugs. This review summarizes the main clinical features of
PAD in patients, the diagnostic process and current medical/interventional approaches, ranging from “classical
treatment” to novel agents.