Peripheral Artery Disease in Diabetes Mellitus: Focus on Novel Treatment Options

Author(s): Andrea Demarchi, Alberto Somaschini, Stefano Cornara, Emmanuel Androulakis*

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 46 , 2020


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Abstract:

Diabetes mellitus (DM) and peripheral artery disease (PAD) are two clinical entities closely associated. They share many pathophysiological pathways such as inflammation, endothelial dysfunction, oxidative stress and pro-coagulative unbalance. Emerging data focusing on agents targeting these pathways may be promising. Moreover, due to the increased cardiovascular risk, there is a growing interest in cardiovascular and “pleiotropic” effects of novel glucose lowering drugs. This review summarizes the main clinical features of PAD in patients, the diagnostic process and current medical/interventional approaches, ranging from “classical treatment” to novel agents.

Keywords: Diabetes mellitus, peripheral artery disease, novel treatments, pro-coagulative unbalance, pleiotropic, endothelial dysfunction.

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Article Details

VOLUME: 26
ISSUE: 46
Year: 2020
Published on: 30 December, 2020
Page: [5953 - 5968]
Pages: 16
DOI: 10.2174/1389201021666201126143217
Price: $65

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