Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer

Author(s): Prescillia Forey, Emeline Cros-Perrial, Charles Dumontet, Lars Petter Jordheim*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 21 , 2021


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Abstract:

Nucleotide metabolism has been targeted for many years and in various clinical settings, including cancer. The increased knowledge of certain enzymes involved in this metabolism and associated cellular processes accumulated over the last few years, gives important information related to the druggability of certain proteins and the use of inhibitors for others. Here, we review recent data on such enzymes with a major interest in drug development, i.e. SAMHD1 and the proteins of the NUDIX family. These include information on their roles in cancer progression, correlations with clinical outcomes in cancer patients, and the development and study of enzymatic inhibitors.

Keywords: NUDIX, MTH1, SAMHD1, cancer, treatment, inhibitors.

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Article Details

VOLUME: 28
ISSUE: 21
Year: 2021
Published on: 25 November, 2020
Page: [4088 - 4116]
Pages: 29
DOI: 10.2174/0929867328666201125120422
Price: $65

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