Background: Single-Nucleotide Polymorphisms (SNPs) in genes responsible for coding
microRNAs (miRNAs) are shown to be crucial in progression of Breast Cancer (BC).
Objective: The purpose of this meta-analysis is to obtain more definitive and reliable results due to the
ambiguity and inconsistency of the previous findings in this regard. This study aimed at clarifying the
association of mir14a polymorphisms with breast cancer.
Methods: We searched PubMed, EMBASE, Web of Science and Google Scholar databases for papers
published before August 10, 2019. Afterward, genotypes’ distribution, genotyping methods and ethnicity
groups were extracted and Overall analyses were conducted. A total number of seventeen researches
on 7676 subjects and 7476 controls were found to meet our criteria in this meta-analysis.
Results: Our observations confirmed the increased risk in breast cancer with rs 2910164 polymorphism
in three genetic models: allele contrast fixed genetic model, Recessive fixed genetic model and
CC vs. GG genetic model (P value 0.0109, 0.0404 and 0.0019, respectively).
Conclusion: The rs2910164 polymorphism is associated with increased breast cancer risk. We suggest
that more multicenter studies with larger samples investigate this matter to further clarify the association
and verify our findings.