Polysarcosine: The Best Alternative of Poly (Ethylene Glycol)

(E-pub Ahead of Print)

Author(s): Manu Singhai, Sankha Bhattacharya*

Journal Name: Current Applied Polymer Science


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Abstract:

Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by wesley and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

Keywords: Polysarcosine, Polypeptoid, PEGylation, Nanomedicine, Biomedical Applications. Poly (Ethylene Glycol).

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Article Details

Published on: 24 November, 2020
(E-pub Ahead of Print)
DOI: 10.2174/2452271604999201124222313
Price: $95

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