Potential Roles of MyomiRs in Cardiac Development and Related Diseases

Author(s): Leila Abkhooie, Mostafa M. Sarabi*, Houman Kahroba, Shirin Eyvazi, Soheila Montazersaheb, Vahideh Tarhriz*, Mohammad S. Hejazi

Journal Name: Current Cardiology Reviews

Volume 17 , Issue 4 , 2021


Article ID: e010621188335
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Abstract:

Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and regulate certain aspects of physiological and pathological processes in myocardiocytes, including cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders. In this review, we have summarized recent findings in the field of epigenetic modulations of myomiRs and cardiac regeneration associated with cardiac diseases.

Keywords: MyomiRs, epigenetic, cardiac development, cardiac diseases, microRNA, cardiac regeneration.

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Article Details

VOLUME: 17
ISSUE: 4
Year: 2021
Published on: 20 July, 2021
Article ID: e010621188335
Pages: 14
DOI: 10.2174/1573403X16999201124201021
Price: $65

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