Background: Pulmonary arterial hypertension is one of the chronic diseases
that affect human health. Microvesicles participate in the communication between cells
by fusing with the recipient cells to transfer the bioactive molecules, such as lipids, proteins,
RNA, etc., to the target cells. Microvesicles are involved in various biological processes
and have the functions of regulating immunity, promoting angiogenesis, and so
on. Microvesicles derived from various cells may become the diagnostic biomarkers or
therapeutic targets for the diseases. Therefore, exploring the role of microvesicles-mediated
cell communication has become a potential therapeutic target for pulmonary arterial
Objective: It is to clarify the classification, features, and mechanism of microvesicles in
cell communication and to discuss the potentially important roles of microvesicles-mediated
cell communication in pulmonary arterial hypertension.
Results: Inflammation is an important pathogenesis of pulmonary arterial hypertension.
Many studies have shown that microvesicles from different cells can participate in the
pathological process of pulmonary arterial hypertension by transferring the inflammatory
factors contained in them.
Conclusion: Microvesicles-mediated cell communication may become the therapeutic
target for pulmonary arterial hypertension.