The recent emergence of novel, pathogenic COVID-19 disease associated with SARSCoV-
2 virus in China and its rapid national and international spread pose a global health emergency.
The development of a new drug is tedious and may take decades to develop and involve multiple steps
like the development of prototypes and phase I to III human trials, which involve the study on small to
large populations to examine the safety and side effects associated with the drug under trials. Due to
continous increase in the number of confirmed cases and deaths, there is an urgent need to develop a
drug that is effective to kill the SARS-CoV-2 virus with fewer side effects to the human body. Therefore,
this review focus on the latest advances in the development for the treatment of COVID-19 disease
associated with SARS-CoV-2 with repositioning of already marketed drug with small molecules,
as well as Chinese traditional medicines with established safety and efficacy which are being used for
different therapeutic uses.
Keywords: SARS-CoV-2, chloroquine, hydroxychloroquine, chinese traditional medicine, inhibitors, stem cells.
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