The native flora of Chile has unique characteristics due to the geographical situation of the country,
with the vast desert in the North, Patagonia in the South, the Andean Mountains on the east and the Pacific
Ocean on the west. This exclusivity is reflected in high concentrations of phytochemicals in the fruits and
leaves of its native plants. Some examples are Aristotelia chilensis (Molina), Stuntz (maqui), Berberis microphylla
G. Forst. (calafate), Peumus boldus Molina (boldo), Ribes magellanicum Poir. (Magellan currant), Ugni
molinae Turcz. (murtilla), Rubus geoides Sm. (miñe miñe), Drimys winteri J.R.Forst. & G.Forst. (canelo),
Luma apiculata (DC.) Burret (arrayán) distributed throughout the entire Chilean territory. Some of these Chilean
plants have been used for centuries in the country's traditional medicine. The most recent studies of phytochemical
characterization of parts of Chilean plants show a wide spectrum of antioxidant compounds, phenolic
components, terpenoids and alkaloids, which have shown biological activity in both in vitro and in vivo studies.
This manuscript covers the entire Chilean territory characterizing the phytochemical profile and reporting some
of its biological properties, focusing mainly on antioxidant, anti-inflammatory, antimicrobial, chemopreventive
and cytotoxic activity, and potential against diabetes, metabolic syndrome and gastrointestinal disorders.