The rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy
of antibiotics, which have transformed medicine and saved millions of lives. Antibiotic resistance
has become a major clinical problem today. In addition, multidrug resistance also develops
various structurally and functionally unrelated toxic compounds. To overcome this problem, a new
target efflux pump was recognized that, if inhibited, reduces the level of resistance or potentiates or
produces a synergistic effect in combination with antibiotics. Keeping this in view, the present review
article aims to describe the families of efflux pumps and the various natural components to be
employed as good efflux pump inhibitors.