Pre- and Post-Conditioning of the Heart: An Overview of Cardioprotective Signaling Pathways

Author(s): Denise Coutinho de Miranda*, Gabriela de Oliveira Faria*, Milla Marques Hermidorff, Fernanda Cacilda dos Santos Silva, Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi

Journal Name: Current Vascular Pharmacology

Volume 19 , Issue 5 , 2021

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Graphical Abstract:


Since the discovery of ischemic pre- and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre- and post-conditioning is promising.

Keywords: Heart, ischemic pre-conditioning, ischemic post-conditioning, pre-pharmacological conditioning, postpharmacological conditioning, remote pre-conditioning, cardioprotective signaling pathway, cardioprotective drugs.

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Article Details

Year: 2021
Published on: 20 November, 2020
Page: [499 - 524]
Pages: 26
DOI: 10.2174/1570161119666201120160619
Price: $65

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