At present, cancer is one of the most common diseases in the world, causing a large number of
deaths and seriously affecting people's health. The traditional treatment of cancer is mainly surgery, radiotherapy
or chemotherapy. Conventional chemotherapy is still an important treatment, but it has some shortcomings,
such as poor cell selectivity, serious side effects, drug resistance and so on. Nanoparticle administration can improve
drug stability, reduce toxicity, prolong drug release time, prolong system half-life, and bring broad prospects
for tumor therapy. Lipid polymer hybrid nanoparticles (LPNs), which combine the advantages of polymer
core and phospholipid shell to form a single platform, have become multi-functional drug delivery platforms.
This review introduces the basic characteristics, structure and preparation methods of LPNs, and discusses targeting
strategies of LPNs in tumor therapy in order to overcome the defects of traditional drug therapy.