Strategies for Preparing Different Types of Lipid Polymer Hybrid Nanoparticles in Targeted Tumor Therapy

Author(s): Yong Zhuang, Yiye Zhao, Bingyue Wang, Qi Wang, Tiange Cai*, Yu Cai*

Journal Name: Current Pharmaceutical Design

Volume 27 , Issue 19 , 2021


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Abstract:

At present, cancer is one of the most common diseases in the world, causing a large number of deaths and seriously affecting people's health. The traditional treatment of cancer is mainly surgery, radiotherapy or chemotherapy. Conventional chemotherapy is still an important treatment, but it has some shortcomings, such as poor cell selectivity, serious side effects, drug resistance and so on. Nanoparticle administration can improve drug stability, reduce toxicity, prolong drug release time, prolong system half-life, and bring broad prospects for tumor therapy. Lipid polymer hybrid nanoparticles (LPNs), which combine the advantages of polymer core and phospholipid shell to form a single platform, have become multi-functional drug delivery platforms. This review introduces the basic characteristics, structure and preparation methods of LPNs, and discusses targeting strategies of LPNs in tumor therapy in order to overcome the defects of traditional drug therapy.

Keywords: Lipid polymer hybrid nanoparticles, preparation method, tumor, active targeting, physical and chemical targeting, chemotherapy.

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Article Details

VOLUME: 27
ISSUE: 19
Year: 2021
Published on: 20 November, 2020
Page: [2274 - 2288]
Pages: 15
DOI: 10.2174/1381612826666201120155558
Price: $65

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