Matrix metalloproteinases (MMPs) are a group of zinc-dependent metalloendopeptidases
that are responsible for the degradation, repair, and remodeling of extracellular matrix components.
MMPs play an important role in maintaining a normal physiological function and preventing
diseases, such as cancer and cardiovascular diseases. Natural products derived from plants have
been used as traditional medicine for centuries. Its active compounds, such as catechin, resveratrol
and quercetin, are suggested to play an important role as MMPs inhibitors, thereby opening new insights
into their applications in many fields, such as pharmaceutical, cosmetic, and food industries.
This review summarises the current knowledge of plant-derived natural products with MMP-modulating
activities. Most of the reviewed plant-derived products exhibit an inhibitory activity on
MMPs. Amongst MMPs, MMP-2 and MMP-9 are the most studied. The expression of MMPs is inhibited
through respective signaling pathways, such as MAPK, NF-κB and PI3 kinase pathways,
which contribute to the reduction in cancer cell behaviors, such as proliferation and migration.
Most studies have employed in vitro models, but a limited number of animal studies and clinical
trials have been conducted. Even though plant-derived products show promising results in modulating
MMPs, more in vivo studies and clinical trials are needed to support their therapeutic applications
in the future.