Cytotoxic T Lymphocyte Antigen 4 Gene +49 A/G (rs231775) Polymorphism and Susceptibility to Systemic Lupus Erythematosus

Author(s): Rania Mohammed Kishk, Maii Abdelraheem Abdellatif, Raghda Elsawi Eldesouki*, Mohamed Fawzy, Shaymaa Abdelraheem Abdelhady, Marwa Mohamed Fouad

Journal Name: Current Rheumatology Reviews

Volume 17 , Issue 2 , 2021


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Abstract:

Aim: To assess the probable role of +49AG polymorphism in susceptibility to SLE in an Egyptian population.

Background: Systemic lupus erythematosus (SLE) is a compound inflammatory chronic disease distinguished through the release of autoantibodies. Cytotoxic T lymphocyte associated antigen-4 is a main down controller of T-cell response; its dysregulation could affect SLE pathogenesis by altered T cells activation to self-antigens.

Objectives: To evaluate the CTLA-4 +49AG allelic and genotype frequency in a sample of the Egyptian population and correlate them with disease susceptibility and clinical severity.

Materials and methods: Including 100 patients with SLE and 100 healthy controls (age and gender matched), CTLA-4 exon 1 49 A>G Genotyping was done using Real-Time PCR.

Results: No difference was noticed in genotype or allele distributions of the studied polymorphism between both groups. Similar genotypes and allele frequencies were established for the 2 groups after their stratification by the age of disease onset, clinical course, or severity.

Conclusion: CTLA-4 +49AG gene polymorphism is not linked with the liability to develop SLE in the studied Egyptian population. Yet it is significantly related to disease severity.

Keywords: Systemic lupus polymorphisms, CTLA-4, SNP genotyping, (rs231775), (+49 A/G), PCR.

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Article Details

VOLUME: 17
ISSUE: 2
Year: 2021
Published on: 19 May, 2021
Page: [247 - 251]
Pages: 5
DOI: 10.2174/1573397116666201119145153
Price: $65

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