Background: γ-Poly-Glutamic Acid (γ-PGA) is a naturally occurring homo-polyamide produced
by various strains of Bacillus. It is made from repeating units of L-glutamic acid, D-glutamic acid,
or both connected through amide linkages between α-amino and γ-carboxylic acid groups. As a biopolymer
substance, the attractive properties of γ-PGA are that it is water-soluble, biodegradable, biocompatible,
non-toxic, non-immunogenic, and edible. Therefore, it can be used as a green and environmentally
friendly biological material.
Methods: The review concentrates on the reports revealing the functions and potential use of γ-PGA
and its derivatives in medicine.
Results & Discussion: γ-PGA is described to possess several properties that may be exploited in medicine.
The biopolymer reportedly has been successfully applied not only as a metal chelator, drug carrier/
deliverer, and gene vector, but also used safely as a vaccine adjuvant, tissue engineering material, and
Conclusion: γ-PGA could be potentially considered as a potential biomedical material in the field of