Vitamin D/VDR in Acute Kidney Injury: A Potential Therapeutic Target

Author(s): Siqing Jiang, Lihua Huang, Wei Zhang*, Hao Zhang*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 19 , 2021


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Abstract:

Despite many strategies and parameters used in clinical practice, the incidence and mortality of acute kidney injury (AKI) are still high with poor prognosis. With the development of molecular biology, the role of vitamin D and vitamin D receptor (VDR) in AKI is drawing increasing attention. Accumulated researches have suggested that Vitamin D deficiency is a risk factor of both clinical and experimental AKI, and vitamin D/VDR could be a promising therapeutic target against AKI. However, more qualitative clinical researches are needed to provide stronger evidence for the clinical application of vitamin D and VDR agonists in the future. Issues like the route and dosage of administration also await more attention. The present review aims to summarize the current works on the role of vitamin D/VDR in AKI and provides some new insight on its therapeutic potential.

Keywords: Vitamin D, Vitamin D receptor, acute kidney injury, deficiency, therapeutic target, dosage.

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Article Details

VOLUME: 28
ISSUE: 19
Year: 2021
Published on: 18 November, 2020
Page: [3865 - 3876]
Pages: 12
DOI: 10.2174/0929867327666201118155625
Price: $65

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