Today, the world is suffering from the pandemic of a novel coronavirus disease (COVID-19), a respiratory
illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic is the third fatal
coronavirus outbreak that has already occurred in the 21st century. Even six months after its emergence, hundreds of
thousands of people are still being infected with SARS-CoV-2, and thousands of lives are lost every day across the world.
No effective therapy has been approved to date for the prevention or treatment of this disease, suggesting the need to
broaden the scope in the search for effective treatments. Throughout history, folk medicine has been successfully used to
treat various ailments in humans and Traditional Chinese Medicine has been instrumental in the containment of a number
of viral diseases. Owing to their high chemical diversity and safety profiles, natural products offer great promises as
potentially effective antiviral drugs. In recent years, a large number of anti-coronaviral phytochemicals with different
mechanisms of action have been identified. Among them, tetra-O-galloyl-β-D-glucose, caffeic acid, and saikosaponin B2
block viral entry. A number of flavonoids inhibit viral proteases. Silvestrol inhibits protein synthesis. Myricetin and
scutellarein inhibit viral replication. Emodin, luteolin, and quercetin demonstrate anti-coronaviral activity by inhibiting
multiple processes in the virus life cycle. In this review, we critically evaluate the findings of the natural product-based
anti-coronaviral research that has been published during last two decades, and attempt to provide a comprehensive
description about their utility as potential broad-spectrum anti-coronaviral drugs, examining leads that may guide/facilitate
anti-SARS-CoV-2 drug development studies.