Heart Failure in Diabetes Mellitus: An Updated Review

Author(s): Catrin Sohrabi, Bunny Saberwal, Wei-Yao Lim, Dimitris Tousoulis, Syed Ahsan, Nikolaos Papageorgiou*

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 46 , 2020


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Abstract:

Diabetes mellitus (DM) and heart failure (HF) are comorbid conditions associated with significant morbidity and mortality worldwide. Despite the availability of novel and effective therapeutic options and intensive glycaemic control strategies, mortality and hospitalisation rates continue to remain high and the incidence of HF persists. In this review, we described the impact of currently available glucose-lowering therapies in DM with a focus on HF clinical outcomes. Non-conventional modes of management and alternative pathophysiological mechanisms with the potential for therapeutic targeting are also discussed.

Keywords: Heart failure, diabetes, T2DM, diabetic cardiomyopathy, HF, DM.

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Article Details

VOLUME: 26
ISSUE: 46
Year: 2020
Published on: 30 December, 2020
Page: [5933 - 5952]
Pages: 20
DOI: 10.2174/1381612826666201118091659
Price: $65

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